Which of the following statements is NOT TRUE about NSAIDs?

A. Acetyl salicylic acid is an irreversible inhibitor of COX enzyme.

B. Acetyl salicylic acid reduces in vivo synthesis of prostaglandins.

C. Its clearance is independent of plasma concentration.

D. Antiplatelet effect of low dose aspirin is related to pre-systemic COX inhibition.

Correct Answer: Its clearance is independent of plasma concentration.

Description: Aspirin follows zero order kinetics at higher doses. (Pseudo zero order drug). Therefore at high dose, amount of drug excreted will be constant. That means clearance is not constant.

Category: Pharmacology

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