Which of the subclass of IgG has the maximum serum concentration?
Correct Answer: IgG1
Description: IgG is the most abundant of the immunoglobulins. It has two heavy and two light chains linked by disulfide bonds. 4 subclasses of IgG are present, each differ from each other based on the amino acid sequence. Each of the 4 subclasses has unique epitopes. The subclasses of IgG are present in different amounts with IgG1>IgG2>IgG3>IgG4. IgG1 subclass has the maximum serum concentration. Ref: Infection, Resistance and Immunity By Julius P. Kreie, 2nd Edition, Page 118
Category:
Microbiology
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