Which of the propeies accounts for ethanol’s use in ethylene glycol poisoning?
Correct Answer: Competitive inhibitor of alcohol dehydrogenase
Description: Ethanol acts by competing with ethylene glycol for alcohol dehydrogenase, the first enzyme in the degradation pathway. Because ethanol has a much higher affinity for alcohol dehydrogenase, about a 100-times greater affinity, it successfully blocks the breakdown of ethylene glycol into glycoaldehyde, which prevents the fuher degradation. Ref: Lehninger Principles of Biochemistry, 4th Edition, Page 336; Updates in Emergency Medicine By John Cahill, 2002, Page 115
Category:
Biochemistry
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