Which of the glands are affected in Fox Fordyce disease?
**Core Concept**
Fox-Fordyce disease is a rare condition characterized by the obstruction of apocrine sweat glands, leading to itchy, comedo-like lesions on the skin. This condition affects the apocrine glands, which are a type of sweat gland that is most active during puberty and adolescence.
**Why the Correct Answer is Right**
The correct answer is related to apocrine glands. Apocrine glands are responsible for producing a milky secretion that is rich in protein and lipids. In Fox-Fordyce disease, the apocrine glands become obstructed, leading to the accumulation of this secretion and the formation of comedo-like lesions. The apocrine glands are found in the axillary and anogenital regions, making these areas the primary sites of Fox-Fordyce disease.
**Why Each Wrong Option is Incorrect**
* **Option A:** Eccrine glands are a different type of sweat gland that are responsible for the production of a clear, watery secretion. They are found all over the body and are not affected in Fox-Fordyce disease.
* **Option B:** Sebaceous glands are responsible for the production of sebum, an oily secretion that helps to lubricate the skin. While they are found in the same areas as apocrine glands, they are not affected in Fox-Fordyce disease.
* **Option D:** Mucous glands are responsible for the production of mucus, a thick, protective secretion that is found in various parts of the body. They are not related to Fox-Fordyce disease.
**Clinical Pearl / High-Yield Fact**
Fox-Fordyce disease is a rare condition that is often misdiagnosed as eczema or acne. It is characterized by itchy, comedo-like lesions on the skin, and is often associated with hormonal changes, particularly during puberty and menopause.
**Correct Answer:** C. Apocrine glands.