Which of the following vitamin enhances absorption of iron?
**Core Concept**
Vitamin B12 plays a crucial role in the absorption of dietary iron, particularly non-heme iron. The mechanism involves the formation of a complex between vitamin B12 and intrinsic factor, which enhances the absorption of non-heme iron in the duodenum and proximal jejunum.
**Why the Correct Answer is Right**
Vitamin B12 binds to intrinsic factor in the stomach, forming a complex that protects vitamin B12 from degradation in the acidic environment. This complex is then absorbed in the ileum, where it is reutilized for various bodily functions, including the maintenance of healthy red blood cells. The presence of vitamin B12 also enhances the absorption of non-heme iron by promoting the formation of a soluble iron complex, which is more easily absorbed by the enterocytes.
**Why Each Wrong Option is Incorrect**
**Option A:** Folate does not directly enhance iron absorption, although it is involved in the synthesis of red blood cells, which are essential for iron utilization.
**Option B:** Vitamin C can enhance non-heme iron absorption, but it is not the primary vitamin involved in this process.
**Option C:** Vitamin E has antioxidant properties but does not play a significant role in iron absorption.
**Clinical Pearl / High-Yield Fact**
Vitamin B12 deficiency can lead to impaired iron absorption, resulting in anemia. This is why patients with pernicious anemia (a condition characterized by vitamin B12 deficiency) may also experience iron deficiency anemia.
**Correct Answer:** C. Vitamin B12.