## Core Concept
Obsessive-Compulsive Disorder (OCD) is a mental health condition characterized by recurring, intrusive thoughts (obsessions) and repetitive behaviors (compulsions) that an individual feels compelled to perform. The treatment of OCD often involves a combination of psychotherapy and pharmacotherapy.

## Why the Correct Answer is Right
The correct answer involves the use of Selective Serotonin Reuptake Inhibitors (SSRIs) and Cognitive Behavioral Therapy (CBT), specifically Exposure and Response Prevention (ERP). SSRIs are a type of medication that increases the levels of serotonin in the brain, which helps to reduce the symptoms of OCD. ERP is a form of CBT that is highly effective for OCD, involving helping the patient to gradually confront their fears and reduce their compulsive behaviors.

## Why Each Wrong Option is Incorrect
- **Option A:** While some antipsychotics may be used in treatment-resistant OCD, they are not the first-line treatment.
- **Option B:** Though other therapies like mindfulness-based approaches may have some benefits, they are not as specifically effective for OCD as SSRIs and CBT/ERP.
- **Option C:** This option might include therapies not specifically indicated for OCD or might not combine pharmacotherapy with psychotherapy effectively.

## Clinical Pearl / High-Yield Fact
A key point to remember is that for OCD, the combination of SSRIs (like fluoxetine, sertraline) and ERP is highly effective. In fact, the American Psychiatric Association and other guidelines suggest that both pharmacotherapy with SSRIs and CBT (particularly ERP) are first-line treatments for OCD.

## Correct Answer Line
**Correct Answer: D. Cognitive Behavioral Therapy (CBT) and Selective Serotonin Reuptake Inhibitors (SSRIs).**