Which of the following syndrome is associated with ectopia lentis?
**Core Concept**
Ectopia lentis refers to the displacement or malposition of the lens in the eye, often resulting from a congenital or acquired condition that affects the zonular fibers or the lens capsule. This condition can lead to vision loss and is commonly associated with systemic diseases.
**Why the Correct Answer is Right**
Ectopia lentis is typically associated with Marfan syndrome, a genetic disorder affecting the connective tissue. The condition leads to weakening of the zonular fibers, causing the lens to become dislocated. Marfan syndrome is characterized by tall stature, long limbs, and aortic root dilation. The ectopia lentis in Marfan syndrome is often bilateral and can be accompanied by other ocular manifestations, such as cataracts and glaucoma.
**Why Each Wrong Option is Incorrect**
**Option A:** **Homocystinuria** - This condition is also associated with ectopia lentis, but it is caused by a deficiency in cystathionine beta-synthase, leading to elevated homocysteine levels. It is not the most common cause of ectopia lentis.
**Option B:** **Trauma** - Blunt trauma to the eye can cause a posterior dislocation of the lens, but it is not a syndrome associated with ectopia lentis.
**Option C:** **Diabetes** - Diabetes mellitus can lead to cataract formation, but it is not typically associated with ectopia lentis.
**Clinical Pearl / High-Yield Fact**
Marfan syndrome is a systemic disorder that affects not only the eyes but also the cardiovascular, musculoskeletal, and integumentary systems. It is essential to recognize the ocular manifestations of Marfan syndrome to diagnose and manage the condition effectively.
**Correct Answer: C. Marfan syndrome**