Dental Which of the following substances play a major role in regulating cell-cell and cell-matrix interaction in cementum? A Sharpey's fibers B Intrinsic fibers C Proteoglycans D Phosphoproteins 💡 Explanation Which of the following substances play a major role in regulating cell-cell and cell-matrix interaction in cementum? ✓ Correct Answer: C. Proteoglycans