**Core Concept**
Ketorolac is a nonsteroidal anti-inflammatory drug (NSAID) that acts as a prostaglandin synthesis inhibitor, primarily through the inhibition of cyclooxygenase (COX) enzymes.

**Why the Correct Answer is Right**
Ketorolac exerts its anti-inflammatory and analgesic effects by inhibiting the COX-1 and COX-2 enzymes, which are involved in the synthesis of prostaglandins. Prostaglandins play a crucial role in mediating pain, inflammation, and fever. By inhibiting these enzymes, ketorolac reduces the production of prostaglandins, leading to a decrease in pain and inflammation.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not accurately describe the mechanism of action of ketorolac.
**Option B:** This option is incorrect because ketorolac does not have a direct effect on histamine release.
**Option C:** This option is incorrect because ketorolac is not a selective COX-2 inhibitor.

**Clinical Pearl / High-Yield Fact**
Ketorolac is a useful alternative to opioid analgesics for short-term pain management, particularly in the postoperative setting. However, it is essential to monitor patients for potential bleeding risks, especially those with a history of gastrointestinal bleeding or taking anticoagulant medications.

**Correct Answer:** C. Ketorolac is a non-selective COX inhibitor.