**Core Concept**
Rabies virus is a lyssavirus, a single-stranded RNA virus that affects the central nervous system (CNS). It is primarily transmitted through the saliva of infected animals, usually through bites. The virus targets the neurons of the CNS, leading to severe neurological symptoms.

**Why the Correct Answer is Right**
Rabies virus is a neurotropic virus, meaning it specifically targets neurons in the CNS. Once infected, neurons undergo apoptosis, leading to inflammation and necrosis of the brain, particularly in the hippocampus, cerebellum, and brainstem. This results in the characteristic symptoms of rabies, including aggression, hydrophobia, and paralysis. The virus is transmitted through the saliva of infected animals, usually through bites, which introduce the virus into the host's bloodstream and eventually into the CNS.

**Why Each Wrong Option is Incorrect**
**Option A:** This is incorrect because rabies virus is not a DNA virus; it is a single-stranded RNA virus.
**Option B:** This is incorrect because rabies virus is primarily transmitted through bites, not through the respiratory route.
**Option C:** This is incorrect because the incubation period of rabies can range from a few days to several months, not just a few weeks.

**Clinical Pearl / High-Yield Fact**
The classic symptoms of rabies include aggression, hydrophobia, and paralysis. The virus can also cause a range of other symptoms, including fever, confusion, and seizures. Prompt medical attention and post-exposure prophylaxis (PEP) can prevent the development of rabies if administered promptly after exposure.

**Correct Answer:** D