Microbiology Which of the following statements is true about isotypic variation ? A These result due to subtle amino acid changes resulting from allelic differences B These result due to changes in amino acid in heavy and light chain at variable region C Changes in heavy and light chain in constant region is responsible for class and subclass of immunoglobulins D These are areas in antigen that bind specifically to antibody 💡 Explanation Which of the following statements is true about isotypic variation ? ✓ Correct Answer: C. Changes in heavy and light chain in constant region is responsible for class and subclass of immunoglobulins