Pharmacology Which of the following statements is not true of local anesthetics? A The local anesthetic is required in the unionized form for penetrating the neuronal membrane B The local anesthetic approaches its receptor only from the intraneuronal face of the Na+ channel C The local anesthetic binds to its receptor mainly when the Na+ channel is in the resting state D The local anesthetic combines with its receptor in the ionized cationic form 💡 Explanation Which of the following statements is not true of local anesthetics? ✓ Correct Answer: C. The local anesthetic binds to its receptor mainly when the Na+ channel is in the resting state