Anatomy Which of the following statements is not true of local anaesthetics? A The local anaesthetic is required in the unionized form for penetrating the neuronal membrane B The local anaesthetic approaches its receptor only from the intraneuronal face of the Na+ channel C The local anaesthetic binds to its receptor mainly when the Na+ channel is in the resting state D The local anaesthetic combines with its receptor in the ionized cationic form 💡 Explanation Which of the following statements is not true of local anaesthetics? ✓ Correct Answer: C. The local anaesthetic binds to its receptor mainly when the Na+ channel is in the resting state