**Question:** Which of the following statements is FALSE about Naltrexone?

A. Naltrexone is a mu-opioid receptor antagonist
B. Naltrexone is primarily used for treating alcohol dependence
C. Naltrexone can be administered orally
D. Naltrexone is contraindicated in patients with liver disease

**Core Concept:** Naltrexone is a medication primarily used for managing substance use disorders, particularly opioid use disorder (OUD) and alcohol dependence. Naltrexone acts as a mu-opioid receptor antagonist, blocking the effects of opioids and reducing cravings.

**Why the Correct Answer is Right:** While all other statements are true, statement B ("Naltrexone is primarily used for treating alcohol dependence") is false. Naltrexone is primarily used for treating opioid dependence, not alcohol dependence. The medication is also approved for alcohol dependence, but its primary indication is for opioid dependence.

**Why Each Wrong Option is Incorrect:**

A. Naltrexone is a mu-opioid receptor antagonist (True)
B. Naltrexone is primarily used for treating alcohol dependence (False)
C. Naltrexone can be administered orally (True)
D. Naltrexone is contraindicated in patients with liver disease (False) - Naltrexone can be used in patients with mild to moderate liver disease after careful assessment by the healthcare provider.

**Clinical Pearl:** Naltrexone is a valuable tool in the management of substance use disorders. While it is primarily used for opioid dependence, it can also be used for alcohol dependence. Importantly, Naltrexone can be administered orally, offering convenience to patients. However, patients with severe liver disease should be carefully evaluated before initiating Naltrexone therapy, as it may not be safe for them.