Pharmacology Which of the following statements best describes the mechanism of action of benzodiazepines ? A Benzodiazepines activate GABAB receptors in the spinal cord B Benzodiazepines block glutamate receptors in neuronal pathways in the brain C They increase the frequency of opening of chloride ion channels that are coupled to GABAA receptors D They are direct acting GABA receptor agonists in the CNS 💡 Explanation Which of the following statements best describes the mechanism of action of benzodiazepines ? ✓ Correct Answer: C. They increase the frequency of opening of chloride ion channels that are coupled to GABAA receptors