Which of the following statements about imipenem is most accurate?
Correct Answer: In renal dysfunction, dosage reductions are necessary to avoid seizures
Description: Carbapenems are synthetic b-lactam antibiotics Imipenem, meropenem, doripenem and eapenem are the drugs of this group currently available. Imipenem : Effective against : Gm +ve, Gm -ve including pseudomonas and anaerobic. Dehydropeptidase by kidney metabolises imipenem rapidly. Cilastatin is a dehydropetidase inhibitor, which must be given along with imipenem for desired action. Side effect : Seizure
Category:
Pharmacology
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