Physiology Which of the following statement is true regarding binding of O2 to hemoglobin? A Results in a release of the heme from the interior to the exterior of the Beta subunits leading to an increase in O2 affinity of the alpha subunits B Causes a large shift of the surrounding secondary structures which leads to decreased affinity of the deoxy subunits for CO2 C Is Cooperative, meaning that after the first O2 binds, the other subunits are more readily oxygenated D Occurs with equal affinity at all four subunits 💡 Explanation Which of the following statement is true regarding binding of O2 to hemoglobin? ✓ Correct Answer: C. Is Cooperative, meaning that after the first O2 binds, the other subunits are more readily oxygenated