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Which of the following statement best describes the mechanism of action of insulin on target cells

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Correct Answer:
Insulin binds to a transmembrane receptor at the which outer suace of the plasma membrane, activates the tyrosine kinase that is the cytosolic domain of the receptor.
Description:
Ref-Goodman and Gilman 12/e p1241) Enzymatic Receptors have two sites, the drug binds on the extracellular site and the intracellular site has enaymatic activity (mostly tyrosine kinase) This enzyme can be activated AK-STAT pathway. Insulin, growthormone, prolactin and cvtokines act enrvmatic receptors.
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