Which of the following statement about Phenytoin is true?
Correct Answer: It follows zero order kinetics
Description: Phenytoin follows zero order kinetics at therapeutic plasma concentration. Other drugs following zero order kinetics are warfarin, alcohol, aspirin, theophylline, and tolbutamide. *Phenytoin is a powerful microsomal enzyme inducer. *Phenytoin is metabolized to inactive products by liver. *Use of Phenytoin during pregnancy can cause Fetal hydantoin syndrome characterized by hypoplastic phalanges, cleft lip, cleft palate and microcephaly. It occurs due to a metabolite of phenytoin, arene oxide. REF: KATZUNG 14TH ED.
Category:
Pharmacology
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