Physiology Which of the following renal alterations would most likely preserve the GFR? A Defect in the elimination of hydrogen ions in the distal tubule B Luminal obstruction by renal tubular casts C Increased interstitial pressure D Decreased intrarenal nitric oxide 💡 Explanation Which of the following renal alterations would most likely preserve the GFR? ✓ Correct Answer: D. Decreased intrarenal nitric oxide