Physiology Which of the following regulators would MOST likely inhibit the lower esophageal sphincter in normal individuals? A Acetylcholine and substance P B Substance P and nitric oxide C Substance P only D Vasoactive intestinal polypeptide and nitric oxide 💡 Explanation Which of the following regulators would MOST likely inhibit the lower esophageal sphincter in normal individuals? ✓ Correct Answer: D. Vasoactive intestinal polypeptide and nitric oxide