Which of the following regarding sickle cell disease is false?

A. Single nucleotide change results in change of Glutamine to Valine

B. Sticky patch is generated as a result of replacement of a nonpolar residue with a polar residue

C. HbS provides resistance against malaria

D. Binding of deoxyHbA terminates fiber polymerization

Correct Answer: Sticky patch is generated as a result of replacement of a nonpolar residue with a polar residue

Description: In HbS, the nonpolar amino acid valine has replaced the polar surface residue Glu6 of the β subunit, generating a hydrophobic “sticky patch” on the surface of the β subunit of both oxyHbS and deoxyHbS. Ref: Harper’s illustrated biochemistry. 30th edition page no: 56

Category: Biochemistry

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