Which of the following RCC do not have papillary architecture in histology ?
Correct Answer: Succinate dehydrogenase-deficient RCC
Description: Succinate dehydrogenase deficient renal cell carcinoma (SDD-RCC) It is very rare type of RCC It is defined by WHO as a malignant epithelial tumor, composed of vacuolated eosinophilic to clear cells with loss of immunohistochemical expression of SDHB gene. Features : Characteristic flocculent cytoplasmic vacuoles with a pale eosinophilic, bubbly appearance and low grade nuclei Image : SDD-RCC showing cytoplasmic vacuoles which impas a bubbly appearance.
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