Which of the following promotes rouleaux formation?
Correct Answer: Fibrinogen
Description: When in circulation, the negative charge on the RBC membrane (or zeta potential) does not allow RBCs to clump. When blood is made to stand in a veical tube, the asymmetric macromolecules in the plasma overcome the zeta potential, so as to form the rouleaux and settling down of the RBC clumps. Fibrinogen and gamma-globulins are the examples of such asymmetric macromolecules. Plasma albumin retards the rouleaux formation. Hence, in nephrotic syndrome, in which the albumin levels fall, there is a rise in ESR.
Category:
Physiology
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