Biochemistry Which of the following occurs in the lipidosis known as Tay-Sachs disease? A Synthesis of a specific ganglioside is excessive B Xanthomas due to cholesterol deposition are observed C Phosphoglycerides accumulate in the brain D Ganglioside GM2 is not catabolized by lysosomal enzymes 💡 Explanation Which of the following occurs in the lipidosis known as Tay-Sachs disease? ✓ Correct Answer: D. Ganglioside GM2 is not catabolized by lysosomal enzymes