Which of the following metabolic abnormality is seen with long term use of loop diuretics?
Correct Answer: Metabolic alkalosis
Description: By inhibiting salt reabsorption in the TAL, loop diuretics increase delivery to the collecting duct. Increased delivery leads to increased secretion of K+ and H+ by the duct, causing hypokalemic metabolic alkalosis. This toxicity is a function of the magnitude of the diuresis and can be reversed by K+ replacement and correction of hypovolemia. Ref: Katzung, 11th edition, Chapter 15.
Category:
Pharmacology
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