Pharmacology Which of the following mechanism is mainly responsible for gentamicin induced ototoxicity ? A Direct hair cell toxicity B Binding to and inhibition of hair cell Na+ K+ ATPase C Non–cumulative toxicity D Bind to Ca2+ channels 💡 Explanation Which of the following mechanism is mainly responsible for gentamicin induced ototoxicity ? ✓ Correct Answer: A. Direct hair cell toxicity