Which of the following may cause Parkinson’s
## Core Concept
Parkinson's disease is a neurodegenerative disorder characterized by the loss of dopamine-producing neurons in the substantia nigra, leading to motor symptoms such as tremors, rigidity, and bradykinesia. Certain drugs and toxins can induce parkinsonian symptoms by affecting the dopaminergic system or mimicking its dysfunction.
## Why the Correct Answer is Right
The correct answer, . is likely related to a drug or toxin known to cause parkinsonian symptoms. One well-known cause of drug-induced parkinsonism is the use of **antipsychotic medications**, particularly **first-generation (typical) antipsychotics** like haloperidol. These drugs block dopamine D2 receptors in the striatum, which can lead to extrapyramidal side effects (EPS) that mimic Parkinson's disease.
## Why Each Wrong Option is Incorrect
* **Option A:** is incorrect because it does not correspond to a known cause of Parkinson's disease or drug-induced parkinsonism.
* **Option B:** is incorrect as it is not specified, but commonly, drugs that cause parkinsonism are those that affect dopamine, such as antipsychotics.
* **Option C:** is incorrect because, similar to option A, it lacks specificity and is not a recognized cause of parkinsonian symptoms.
## Clinical Pearl / High-Yield Fact
A key point to remember is that **antipsychotic medications**, especially the first-generation types, can cause drug-induced parkinsonism. This is a critical consideration in psychiatric patients treated with these medications, as it can significantly impact their quality of life.
## Correct Answer Line
**Correct Answer: D.**