Based on periodontal research, it would appear that if a root surface conditioning agent were to be used during periradicular surgery, EDTA might be the most appropriate solution. However, the manufacturer (personnel communication, Dr.  Torabinejad)  has  advised  against  the  use  of  EDTA  when mineral trioxide aggregate (MTA) is used as a root-end filling material,  because  it  may  interfere  with  the  hard  tissue–producing effect of MTA. Reference: Cohen Pathways of pulp 11th ed page no 416