Which of the following is Y-linked disease
**Core Concept**
A Y-linked disease, also known as a Y-chromosomal disease, is a condition caused by mutations in genes on the Y chromosome. Since the Y chromosome is passed solely from father to son, these diseases are typically inherited in a pattern that only affects males.
**Why the Correct Answer is Right**
One example of a Y-linked disease is SRY-related protein, also known as spermatogenesis-related protein (SPRY4), which is responsible for sex determination. However, the most well-known Y-linked disease is probably Deafness, Dihydrouracil Nucleosidase deficiency (DDHNU), also known as Y-linked deafness. This condition affects the ability to hear and is caused by mutations in the SLC6A1 gene on the Y chromosome.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it is not a known Y-linked disease. The question is specifically asking for a Y-linked disease, and this option does not match the criteria.
**Option B:** This option is incorrect because it is not a Y-linked disease. The question is specifically asking for a Y-linked disease, and this option does not match the criteria.
**Option C:** This option is incorrect because it is not a Y-linked disease. The question is specifically asking for a Y-linked disease, and this option does not match the criteria.
**Clinical Pearl / High-Yield Fact**
Y-linked diseases are relatively rare compared to X-linked or autosomal diseases, but they are an important consideration in genetic counseling for families with a history of these conditions.
**Correct Answer: D. Deafness, Dihydrouracil Nucleosidase deficiency (DDHNU)**