Microbiology Which of the following is true about isotypic variation? A Subtle amino acid changes due to allelic difference B Changes in a heavy and light chain in variable region C Changes in heavy and light chain in constant region responsible for class and subtype D These are areas in antigen that bind specifically to antibody 💡 Explanation Which of the following is true about isotypic variation? ✓ Correct Answer: C. Changes in heavy and light chain in constant region responsible for class and subtype