Which of the following is the treatment of choice in patients with neurogenic diabetes insipidus?
Correct Answer: Desmopressin
Description: The signs and symptoms of uncomplicated pituitary DI can be eliminated completely by treatment with Desmopressin (DDAVP), a synthetic analogue of AVP. It acts selectively at V2 receptors to increase urine concentration and decrease urine flow in a dose-dependent manner. It is also more resistant to degradation than AVP and has a three-to four fold longer duration of action. Desmopressin (DDAVP) can be given by IV or SC injection, nasal inhalation, or oral tablet.
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