Which of the following is the only hemolytic anaemia caused by acquired intrinsic defect in the cell membrane:
Correct Answer: PNH
Description: PNH is the only hemolytic anemia caused by an acquired intrinsic defect in the cell membrane.
The stem cells of the bone marrow acquire mutations in Phosphatidyl inositol glycan A (PIGA) gene.
The triad of hemolysis, pancytopenia and thrombosis is unique to PNH.
Thrombosis is the leading cause of disease related death in PNH.
Category:
Pathology
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