Medicine Which of the following is the most likely effect of increased levels of red blood cell 2,3 diphosphoglycerate (2,3-DPG)? A hemolytic anemia due to sulfa drugs B increased oxygen affinity C decreased oxygen affinity D loss of red cell energy 💡 Explanation Which of the following is the most likely effect of increased levels of red blood cell 2,3 diphosphoglycerate (2,3-DPG)? ✓ Correct Answer: C. decreased oxygen affinity