Which of the following is the most common inherited malignancy :
Correct Answer: Retinoblastoma
Description: "Retinoblastoma is the most strking example of inhirited cancer syndrome. Approximately 40% of retinoblastomas are familial. Carrier of this gene have a 10000 fold increased risk of developing retinoblastoma usualy bilateral".
Each child of parent with familial bilateral retinoblastoam has a 50% risk of inheriting the retinoblastoma gene, of these 90% will develop retinoblastoma.
Category:
Pediatrics
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