Which of the following is the most common hematological malignancy in children with Down syndrome?
Correct Answer: Acute megakaryoblastic leukemia
Description: Children with trisomy 21 have a high risk of developing leukemia. There is 20-fold increased risk of developing acute B lymphoblastic leukemias. There is 500-fold increased risk of acute myeloid leukemias, most commonly, acute megakaryoblastic leukemia.
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Pathology
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