Which of the following is the mechanism of action of tetanospasmin –
Correct Answer: Inhibition of release of GABA and glycine
Description: Ans. is 'a1 i.e.. Inhibition of release of GABA and glycinePathogenicityo CL tetani has little invasive property and is confined to the primary site of lodgment. Tetanus results from the action of the potent exotoxin it produces.Toxin (released in the wound)|binds to peripheral motor neuron terminals|Enters the axon|Transported to cell body in the brain stem and spinal cord by retrograde intraneural transport|Presynaptically blocks release of glycine & GABAToxinsTetanolysin (Hemolysin)Not relevant in the pathogenesis of tetanus.Tetanospasmin (neurotoxin)Responsible for tetanusIt is plasmid codedIn the brainstem and spinal cord it blocks release of the inhibitory neurotransmitter glycine and g-aminobutyric acid (GABA).It resembles strychnine in its effects, but it acts presynaptically, while strychnine acts postsynapticatly.Tetanus toxin and botulinum toxin resemble each other in their aminoacid sequences.Nonspasmogenic, peripherally active neurotoxin.Its role is not known.
Category:
Microbiology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now