Biochemistry Which of the following is the earliest event in the clotting cascade? A Binding of platelets to red blood cells B Binding of vitamin K to endothelial cell surfaces C Release of tissue factor by damaged vessels D Secretion of von Willebrand factor by platelets 💡 Explanation Which of the following is the earliest event in the clotting cascade? ✓ Correct Answer: C. Release of tissue factor by damaged vessels