Pathology Which of the following is the chief mediator associated with resetting the hypothalamic temperature set point at a higher level, resulting in fever? A PGF2 alpha B PGE1 C PGE2 D PGI2 💡 Explanation Which of the following is the chief mediator associated with resetting the hypothalamic temperature set point at a higher level, resulting in fever? ✓ Correct Answer: C. PGE2