Which of the following is seen in Addison’s disease: September 2007
**Core Concept**
Addison's disease is a rare endocrine disorder characterized by the insufficient production of cortisol and aldosterone hormones due to adrenal gland damage. This leads to a decrease in the production of these essential hormones, affecting various bodily functions.
**Why the Correct Answer is Right**
In Addison's disease, the adrenal glands are damaged, resulting in the decreased production of cortisol and aldosterone. Cortisol is crucial for maintaining blood pressure, regulating blood sugar levels, and aiding in the metabolism of fat, protein, and carbohydrates. Aldosterone, on the other hand, helps regulate electrolyte balance, particularly sodium and potassium. The decreased production of these hormones leads to a variety of symptoms, including hypotension, hyperkalemia, and fatigue.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect as it does not directly relate to the hallmark features of Addison's disease. While hypoglycemia can occur due to cortisol deficiency, it is not the most characteristic feature of the disease.
**Option B:** This option is incorrect as it is more commonly associated with Cushing's syndrome, a condition caused by excessive cortisol production.
**Option C:** This option is incorrect as it is a symptom of Cushing's syndrome, not Addison's disease.
**Clinical Pearl / High-Yield Fact**
One of the key distinguishing features of Addison's disease is the presence of hyperkalemia, which can be life-threatening if not promptly treated. This is due to the decreased production of aldosterone, leading to impaired potassium excretion.
**Correct Answer: D. Hyperkalemia.**