Pathology Which of the following is not true regarding super-antigens – A Bind T cells irrespective of antigen specificity of TCR B Bind directly to both MHC II and T cell receptor causing T cell activation C Bind to cleft (or antigen binding groov(e) in the MHC II molecule D Binds directly to lateral aspect of T cell receptor 💡 Explanation Which of the following is not true regarding super-antigens - ✓ Correct Answer: C. Bind to cleft (or antigen binding groov(e) in the MHC II molecule