Medical MCQ-Which of the following is not true for rifabutin as compared to rifampicin?

Which of the following is not true for rifabutin as compared to rifampicin?

Rifabutin has the longer half-life than rifampicin

Rifabutin has lesser incidence of drug-interactions

Rifabutin is more efficacious against MAC as compared to rifampicin

Rifabutin is more efficacious for pulmonary TB as compared to rifampicin

Question Category:

Pharmacology

Correct Answer:

Rifabutin is more efficacious for pulmonary TB as compared to rifampicin

Description:

Ans: D. Rifabutin is more efficacious for pulmonary TB as compared to rifampicin(Ref Goodman Gilman 12/e p1550, 1552, 1554, 1568; Katzung 12/e p845)Rifabutin:Stronger activity against Mycobacterium avium complex (compared to rifampicin).Ineffective against Mycobacterium tuberculosis. RifabutinRifampicin (Rifampin)RifapentineProtein binding 718597Oral 2068deg-tmax (hours)2.5-4.01.5-2.05.0-6.0degHalf-life (hours)32-67deg2-5deg14-18Intracellular/extracellular9524-60degAutoinduction40%deg38%20%CYP3A inductionWeakPronouncedModerateCYP3A substrateYesdegNoNo

Previous MCQ

Next MCQ

Get More

Subject Mock Tests

Try practicing mock tests with over 200,000 questions from various medical subjects.

Attempt a mock test now

Mock Exam

Attempt an exam of 100 questions randomly chosen from all subjects.

Coming Soon