Which of the following is not true about medullary thyroid carcinoma?
Correct Answer: Form about 25% of the thyroid malignancies
Description: Ans. is 'c' i.e., Form about 25% of the thyroid malignancies Medullary carcinoma of thyroid* Medullary carcinomas of the thyroid are neuroendocrine neoplasms derived from the parafollicular cells, or C cells, of the thyroid, and account for approximately 5% of thyroid neoplasms.* Medullary carcinomas, similar to normal C cells, secrete calcitoniny the measurement of which plays an important role in the diagnosis and postoperative follow-up of patients.* In some instances the tumor cells elaborate other polypeptide hormones, such as serotonin, ACTH, and vasoactive intestinal peptide (VIP).* About 70% of tumors arise sporadically. The remainder occurs in the setting of MEN syndrome 2A or 2B or as familial tumors without an associated MEN syndrome.* Activating point mutations in the RET proto-oncogene play an important role in the development of both familial and sporadic medullary carcinomas.
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