Which of the following is not true about chromothrypsis?

A. It is associated with chromosome rearrangements termed as chromosome shattering.

B. It is observed in 1% to 2% of cancers as a whole.

C. Associated with inactivation of oncogenes and activation of tumor suppressors.

D. Increased frequency of 25% of osteosarcomas and high frequency in gliomas

Correct Answer: Associated with inactivation of oncogenes and activation of tumor suppressors.

Description: Chromothrypsis Phenomenon by which up to thousands of clustered chromosomal rearrangements occur in a single event in localized and confined genomic regions Involved in cancer (1% -2%)and congenital diseases. Osteosarcomas and gliomas as well. Chromosome breaks occur within pa or across the entirety of a single chromosome or several chromosomes. Activate oncogenes and inactivate tumor suppressors, thereby expediting the process of carcinogenesis.

Category: Pathology

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