Pathology Which of the following is not true about chromothrypsis? A It is associated with chromosome rearrangements termed as chromosome shattering. B It is observed in 1% to 2% of cancers as a whole. C Associated with inactivation of oncogenes and activation of tumor suppressors. D Increased frequency of 25% of osteosarcomas and high frequency in gliomas 💡 Explanation Which of the following is not true about chromothrypsis? ✓ Correct Answer: C. Associated with inactivation of oncogenes and activation of tumor suppressors.