Which of the following is not true about Brugada syndrome
**Core Concept**
Brugada syndrome is a genetic disorder characterized by abnormal electrocardiogram (ECG) findings and an increased risk of sudden cardiac death. It is caused by mutations in genes that encode for cardiac sodium channels, leading to abnormal cardiac repolarization and arrhythmias.
**Why the Correct Answer is Right**
The hallmark of Brugada syndrome is the presence of a coved-type ST-segment elevation in the right precordial leads (V1-V2) on an ECG, often accompanied by a saddleback or coved pattern. This is due to the abnormal function of the cardiac sodium channels, specifically the SCN5A gene, which encodes for the alpha-subunit of the sodium channel. The mutation leads to a reduction in the sodium current (INa) during the action potential, resulting in a delay in cardiac repolarization and an increased risk of arrhythmias.
**Why Each Wrong Option is Incorrect**
**Option A:** Brugada syndrome is often associated with a family history of sudden cardiac death, which is incorrect. While family history is a risk factor, it is not a defining characteristic of Brugada syndrome.
**Option B:** The ECG findings in Brugada syndrome are characterized by a coved-type ST-segment elevation, which is correct. This is a key diagnostic feature of the condition.
**Option C:** Brugada syndrome is often associated with a mutation in the SCN5A gene, which is correct. This gene encodes for the alpha-subunit of the sodium channel and is a common cause of the condition.
**Option D:** Brugada syndrome is not typically associated with a left bundle branch block (LBBB) pattern on an ECG, which is correct. While some patients may have a LBBB pattern, it is not a characteristic feature of the condition.
**Clinical Pearl / High-Yield Fact**
A key diagnostic feature of Brugada syndrome is the presence of a coved-type ST-segment elevation in the right precordial leads (V1-V2) on an ECG, often accompanied by a saddleback or coved pattern.
**Correct Answer:** D.