Which of the following is not true about Berger’s disease –
**Core Concept**
Berger's disease, also known as IgA nephropathy, is a type of kidney disease characterized by the deposition of IgA antibodies in the glomeruli. It is the most common cause of kidney disease worldwide. The underlying principle involves an abnormal immune response.
**Why the Correct Answer is Right**
Since the correct answer is not specified, let's discuss the general characteristics of Berger's disease. It is often associated with hematuria, particularly after an upper respiratory tract infection. The disease can progress to end-stage renal disease in some cases. The exact mechanism involves the deposition of IgA antibodies, which can activate the alternative complement pathway.
**Why Each Wrong Option is Incorrect**
**Option A:** Without the specific details of option A, we cannot provide a direct explanation. However, if it stated that Berger's disease is an autoimmune disease, that would be incorrect because its exact pathogenesis is still debated.
**Option B:** Similarly, without specifics, if option B mentioned that Berger's disease only affects children, that would be incorrect as it can occur at any age.
**Option C:** If option C suggested that Berger's disease is always asymptomatic, that would be incorrect because patients often present with visible hematuria.
**Option D:** If option D stated that Berger's disease has a cure, that would be incorrect as treatment is mainly supportive.
**Clinical Pearl / High-Yield Fact**
Berger's disease is notable for its association with synpharyngitic hematuria, where bleeding is seen shortly after an upper respiratory infection. This is a key clinical feature to remember.
**Correct Answer:**