Which of the following is not seen in hypothyrodism?
**Core Concept**
Hypothyroidism is a condition characterized by reduced production of thyroid hormones, primarily triiodothyronine (T3) and thyroxine (T4), leading to decreased metabolic rate, fatigue, and various other systemic effects.
**Why the Correct Answer is Right**
The correct answer is related to the pathophysiology of hypothyroidism. Hypothyroidism leads to decreased production of thyroid hormones, which in turn affects various bodily functions. One of the consequences of decreased thyroid hormone production is a decrease in the breakdown of glycogen to glucose, resulting in increased glycogen levels. This is due to the inhibition of the enzyme glycogen phosphorylase, which is responsible for the breakdown of glycogen to glucose-1-phosphate.
**Why Each Wrong Option is Incorrect**
**Option A:**
* Incorrect because increased levels of cholesterol are commonly seen in hypothyroidism due to decreased conversion of cholesterol to bile acids.
**Option B:**
* Incorrect because decreased levels of T3 and T4 lead to decreased metabolic rate, which results in weight gain, not loss.
**Option C:**
* Incorrect because increased levels of creatine kinase (CK) are seen in hypothyroidism due to muscle damage and increased muscle mass.
**Clinical Pearl / High-Yield Fact**
In hypothyroidism, the skin may become dry, thickened, and brittle due to decreased metabolism and increased levels of mucopolysaccharides.
**Correct Answer: D. Increased glycogen levels.**