**Core Concept**
Alport's syndrome is a genetic disorder characterized by glomerulonephritis, end-stage kidney disease, and hearing loss. It is caused by mutations in the COL4A3, COL4A4, or COL4A5 genes encoding type IV collagen, a critical component of the glomerular basement membrane.

**Why the Correct Answer is Right**
Alport's syndrome is associated with the presence of red blood cell hemolysis, hematuria, and proteinuria due to the disruption of the glomerular filtration barrier. The absence of red blood cell hemolysis makes option C the correct answer, as hemolysis is not a characteristic feature of Alport's disease.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect as Alport's syndrome indeed involves the presence of hematuria, which is a hallmark of the disease.
**Option B:** This option is incorrect as proteinuria is a common finding in Alport's syndrome due to the compromised glomerular filtration barrier.
**Option D:** This option is incorrect as end-stage kidney disease is a characteristic feature of Alport's syndrome, often requiring renal replacement therapy.

**Clinical Pearl / High-Yield Fact**
It is essential to note that Alport's syndrome is an X-linked condition, and females are often carriers, while males are more frequently affected due to the presence of a single X chromosome. Understanding the genetic basis of Alport's syndrome is crucial for accurate diagnosis and management.

**Correct Answer:** C.