**Core Concept**
Ophthalmia neonatorum refers to any conjunctivitis or keratitis occurring in the first month of life, often resulting from infections during birth. The management of ophthalmia neonatorum involves administering appropriate antibiotics to cover common pathogens.

**Why the Correct Answer is Right**
The correct answer is typically not given in ophthalmia neonatorum due to the risk of resistance development. In most cases, ophthalmia neonatorum is caused by Neisseria gonorrhoeae or Chlamydia trachomatis, which are often treated with antibiotics such as ceftriaxone and azithromycin, respectively. However, in cases where the causative agent is unknown or resistant, the first-line treatment may not be given.

**Why Each Wrong Option is Incorrect**
**Option A:** This option may be given in ophthalmia neonatorum, especially if the causative agent is Neisseria gonorrhoeae.
**Option B:** This option may be given in ophthalmia neonatorum, especially if the causative agent is Chlamydia trachomatis.
**Option D:** This option may be given in ophthalmia neonatorum, especially if the causative agent is resistant to first-line treatment.

**Clinical Pearl / High-Yield Fact**
In cases of ophthalmia neonatorum, it's essential to perform a thorough maternal and neonatal history to identify potential risk factors and guide appropriate antibiotic treatment. A high index of suspicion is crucial to prevent long-term vision loss.

**Correct Answer: C. Doxycycline is generally avoided in neonates due to the risk of teeth discoloration and inhibition of bone growth.**