Which of the following is not found in DiGeorge’s syndrome?
**Core Concept**
DiGeorge's syndrome, also known as 22q11.2 deletion syndrome, is a congenital disorder caused by a deletion of a small segment of chromosome 22. This deletion leads to various clinical manifestations, including congenital heart defects, cleft palate, and immunodeficiency.
**Why the Correct Answer is Right**
The characteristic features of DiGeorge's syndrome include thymic hypoplasia, leading to T-cell immunodeficiency, hypoparathyroidism due to parathyroid gland aplasia, and congenital heart defects. The thymus is crucial for T-cell development, and its hypoplasia results in impaired cell-mediated immunity. The parathyroid glands are responsible for calcium homeostasis, and their aplasia leads to hypocalcemia.
**Why Each Wrong Option is Incorrect**
**Option A:** Although not a primary feature, some patients with DiGeorge's syndrome may have cleft palate, making this option incorrect.
**Option B:** Congenital heart defects are a common feature of DiGeorge's syndrome, making this option incorrect.
**Option C:** Cytomegalovirus (CMV) infection is not a characteristic feature of DiGeorge's syndrome, making this option incorrect.
**Clinical Pearl / High-Yield Fact**
DiGeorge's syndrome is often associated with other congenital anomalies, including cardiac defects, cleft palate, and palatal abnormalities. The clinical presentation can vary widely among affected individuals.
**Correct Answer: C. Cytomegalovirus (CMV) infection**